文章基本信息

标题：Whole-exome sequencing reveals genetic variants associated with chronic kidney disease characterized by tubulointerstitial damages in North Central Region, Sri Lanka
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作者：Shanika Nanayakkara ; STMLD Senevirathna ; Nipuna B. Parahitiyawa 等
期刊名称：Environmental Health and Preventive Medicine
印刷版ISSN：1342-078X
电子版ISSN：1347-4715
出版年度：2015
卷号：20
期号：5
页码：354-359
DOI：10.1007/s12199-015-0475-1
语种：English
出版社：Springer Japan
摘要：Objectives
The familial clustering observed in chronic kidney disease of uncertain etiology (CKDu) characterized by tubulointerstitial damages in the North Central Region of Sri Lanka strongly suggests the involvement of genetic factors in its pathogenesis. The objective of the present study is to use whole-exome sequencing to identify the genetic variants associated with CKDu.
关键词：Chronic kidney disease ;Sri Lanka ; KCNA10 ; LAMB2 ;Genetic susceptibility