文章基本信息

标题：The Role of Gluten in Celiac Disease and Type 1 Diabetes
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作者：Gloria Serena
期刊名称：Nutrients
电子版ISSN：2072-6643
出版年度：2015
卷号：7
期号：9
页码：7143-7162
DOI：10.3390/nu7095329
语种：English
出版社：MDPI Publishing
摘要：Celiac disease (CD) and type 1 diabetes (T1D) are autoimmune conditions in which dietary gluten has been proven or suggested to play a pathogenic role. In CD; gluten is established as the instigator of autoimmunity; the autoimmune process is halted by removing gluten from the diet; which allows for resolution of celiac autoimmune enteropathy and subsequent normalization of serological markers of the disease. However; an analogous causative agent has not yet been identified for T1D. Nevertheless; the role of dietary gluten in development of T1D and the potentially beneficial effect of removing gluten from the diet of patients with T1D are still debated. In this review; we discuss the comorbid occurrence of CD and T1D and explore current evidences for the specific role of gluten in both conditions; specifically focusing on current evidence on the effect of gluten on the immune system and the gut microbiota.
关键词：celiac disease; type 1 diabetes; gluten celiac disease ; type 1 diabetes ; gluten