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标题：Dietary Sources of Vitamin B-12 and Their Association with Vitamin B-12 Status Markers in Healthy Older Adults in the B-PROOF Study
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作者：Elske M. Brouwer-Brolsma ; Rosalie A. M. Dhonukshe-Rutten
期刊名称：Nutrients
电子版ISSN：2072-6643
出版年度：2015
卷号：7
期号：9
页码：7781-7797
DOI：10.3390/nu7095364
语种：English
出版社：MDPI Publishing
摘要：Low vitamin B-12 concentrations are frequently observed among older adults. Malabsorption is hypothesized to be an important cause of vitamin B-12 inadequacy, but serum vitamin B-12 may also be differently affected by vitamin B-12 intake depending on food source. We examined associations between dietary sources of vitamin B-12 (meat, fish and shellfish, eggs, dairy) and serum vitamin B-12, using cross-sectional data of 600 Dutch community-dwelling adults (≥65 years). Dietary intake was assessed with a validated food frequency questionnaire. Vitamin B-12 concentrations were measured in serum. Associations were studied over tertiles of vitamin B-12 intake using P for trend, by calculating prevalence ratios (PRs), and splines. Whereas men had significantly higher vitamin B-12 intakes than women (median (25th–75th percentile): 4.18 (3.29–5.38) versus 3.47 (2.64–4.40) μg/day), serum vitamin B-12 did not differ between the two sexes (mean ± standard deviation (SD): 275 ± 104 pmol/L versus 290 ± 113 pmol/L). Higher intakes of dairy, meat, and fish and shellfish were significantly associated with higher serum vitamin B-12 concentrations, where meat and dairy—predominantly milk were the most potent sources. Egg intake did not significantly contribute to higher serum vitamin B-12 concentrations. Thus, dairy and meat were the most important contributors to serum vitamin B-12, followed by fish and shellfish.
关键词：vitamin B-12 intake; serum vitamin B-12; dairy; milk; yoghurt; cheese; meat; fish and shellfish; eggs vitamin B-12 intake ; serum vitamin B-12 ; dairy ; milk ; yoghurt ; cheese ; meat ; fish and shellfish ; eggs