文章基本信息

标题：Hyperpolarized ¹⁵N-pyridine Derivatives as pH-Sensitive MRI Agents
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作者：Weina Jiang ; Lloyd Lumata ; Wei Chen 等
期刊名称：Scientific Reports
电子版ISSN：2045-2322
出版年度：2015
卷号：5
DOI：10.1038/srep09104
出版社：Springer Nature
摘要：Highly sensitive MR imaging agents that can accurately and rapidly monitor changes in pH would have diagnostic and prognostic value for many diseases. Here, we report an investigation of hyperpolarized ¹⁵N-pyridine derivatives as ultrasensitive pH-sensitive imaging probes. These molecules are easily polarized to high levels using standard dynamic nuclear polarization (DNP) techniques and their ¹⁵N chemical shifts were found to be highly sensitive to pH. These probes displayed sharp ¹⁵N resonances and large differences in chemical shifts (Δδ >90 ppm) between their free base and protonated forms. These favorable features make these agents highly suitable candidates for the detection of small changes in tissue pH near physiological values.