文章基本信息

标题：New Anti-angiogenic Leading Structure Discovered in the Fruit of Cimicifuga yunnanensis
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作者：Yin Nian ; Jing Yang ; Tong-Yang Liu 等
期刊名称：Scientific Reports
电子版ISSN：2045-2322
出版年度：2015
卷号：5
DOI：10.1038/srep09026
出版社：Springer Nature
摘要：Cimyunnins A–C (1–3), characterized with an unusual fused cyclopentenone ring G, together with cimyunnin D (4), possessing a highly rearranged γ -lactone ring F, were characterized from the fruit of Cimicifuga yunnanensis . Their structures were elucidated by spectroscopic analysis, X-ray diffraction, and density functional theory calculations. In addition, cimyunnin A exhibited comparable anti-angiogenic activities to those of sunitinib, a clinically-used first-line angiogenesis inhibitor, in the in vitro and ex vivo studies.