文章基本信息

标题：Biological interaction of living cells with COSAN-based synthetic vesicles
本地全文：下载
作者：Màrius Tarrés ; Elisabetta Canetta ; Eleanor Paul 等
期刊名称：Scientific Reports
电子版ISSN：2045-2322
出版年度：2015
卷号：5
DOI：10.1038/srep07804
出版社：Springer Nature
摘要：Cobaltabisdicarbollide (COSAN) [3,3′-Co(1,2-C₂B₉H₁₁)₂]⁻, is a complex boron-based anion that has the unusual property of self-assembly into membranes and vesicles. These membranes have similar dimensions to biological membranes found in cells, and previously COSAN has been shown to pass through synthetic lipid membranes and those of living cells without causing breakdown of membrane barrier properties. Here, we investigate the interaction of this inorganic membrane system with living cells. We show that COSAN has no immediate effect on cell viability, and cells fully recover when COSAN is removed following exposure for hours to days. COSAN elicits a range of cell biological effects, including altered cell morphology, inhibition of cell growth and, in some cases, apoptosis. These observations reveal a new biology at the interface between inorganic, synthetic COSAN membranes and naturally occurring biological membranes.