文章基本信息

标题：Changes in vaginal microbiota following antimicrobial and probiotic therapy
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作者：Jean M Macklaim ; Jose C Clemente ; Rob Knight 等
期刊名称：Microbial Ecology in Health and Disease
印刷版ISSN：1651-2235
出版年度：2015
卷号：26
期号：0
DOI：10.3402/mehd.v26.27799
语种：English
出版社：Microbial Ecology in Health and Disease
摘要：Background: The composition of the vaginal microbiota is known to be important for health. When infections occur, antimicrobial therapy is often poorly efficacious.Objective and design: We used 16S rRNA gene sequencing to characterize changes in the bacterial microbiota following oral antimicrobial and probiotic interventions.Results: While the bacterial vaginal profiles of women with vulvovaginal candidiasis were dominated by lactobacilli as in healthy women, and unchanged by therapy, Gardnerella vaginalis, Prevotella, Atopobium, Sneathia, and Megasphaera dominated the vagina of women with bacterial vaginosis (BV), and treatment with tinidazole plus Lactobacillus reuteri RC-14+L. rhamnosus GR-1 resulted in an increased relative abundance of indigenous L. iners or L. crispatus.Conclusions: The ability to restore homeostasis provides a rationale for conjoint use of probiotics with antibiotic treatment of BV.Keywords: Lactobacillus; bacterial vaginosis; vulvovaginal candidiasis; probiotics(Published: 14 August 2015)Citation: Microbial Ecology in Health & Disease 2015, 26: 27799 - http://dx.doi.org/10.3402/mehd.v26.27799
关键词：Lactobacillus; bacterial vaginosis; vulvovaginal candidiasis; probiotics