文章基本信息

标题：Next-generation sequencing of the mitochondrial genome and association with IgA nephropathy in a renal transplant population
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作者：Adam P. Douglas ; Dwaine R. Vance ; Elaine M. Kenny 等
期刊名称：Scientific Reports
电子版ISSN：2045-2322
出版年度：2014
卷号：4
DOI：10.1038/srep07379
出版社：Springer Nature
摘要：Kidneys are highly aerobic organs that are critically dependent on the normal functioning of mitochondria. Genetic variations disrupting mitochondrial function are associated with multifactorial disorders including kidney disease. This study sequenced the entire mitochondrial genome in a renal transplant cohort of 64 individuals, using next-generation sequencing, to evaluate the association of genetic variants with IgA nephropathy and end-stage renal disease (ESRD, n = 100).