文章基本信息

标题：Selecting water-alcohol mixed solvent for synthesis of polydopamine nano-spheres using solubility parameter
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作者：Xiaoli Jiang ; Yinling Wang ; Maoguo Li 等
期刊名称：Scientific Reports
电子版ISSN：2045-2322
出版年度：2014
卷号：4
DOI：10.1038/srep06070
出版社：Springer Nature
摘要：The solvent plays an important role in a given chemical reaction. Since most reaction in nature occur in the mixed-solvent systems, a comprehensive principle for solvent optimization was required. By calculating the Hansen solubility parameters (HSP) distance R_a , we designed a model experiment to explore the influence of mixed solvents on the chemical synthesis. The synthesis of polydopamine (PDA) in the water-alcohol system was chosen as model. As predicted, the well-dispersed PDA spheres were obtained in selected solvents with smaller R_a values: methanol/water, ethanol/water and 2-propanol/water. In addition, the mixed solvent with smaller R_a values gave a higher conversion of dopamine. The strategy for mixed solvent selection is might be useful to choose optimal reaction media for efficient chemical synthesis.