文章基本信息

标题：Type 2C Protein Phosphatase Is a Key Regulator of Antiviral Extreme Resistance Limiting Virus Spread
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作者：Jang-Kyun Seo ; Sun-Jung Kwon ; Won Kyong Cho 等
期刊名称：Scientific Reports
电子版ISSN：2045-2322
出版年度：2014
卷号：4
DOI：10.1038/srep05905
出版社：Springer Nature
摘要：Effector-triggered immunity (ETI) is an active immune response triggered by interactions between host resistance proteins and their cognate effectors. Although ETI is often associated with the hypersensitive response (HR), various R genes mediate an HR-independent process known as extreme resistance (ER). In the soybean- Soybean mosaic virus (SMV) pathosystem, the strain-specific CI protein of SMV functions as an effector of Rsv3- mediated ER. In this study, we used the soybean ( Rsv3 )-SMV ( CI ) pathosystem to gain insight into the molecular signaling pathway involved in ER. We used genome-wide transcriptome analysis to identify a subset of the type 2C protein phophatase ( PP2C ) genes that are specifically up-regulated in Rsv3 -mediated ER. Gain-of-function analysis of the most significantly expressed soybean PP2C gene, GmPP2C3a , showed that ABA-induced GmPP2C3a functions as a key regulator of Rsv3 -mediated ER. Our results further suggest that the primary mechanism of ER against viruses is the inhibition of viral cell-to-cell movement by callose deposition in an ABA signaling-dependent manner.