文章基本信息

标题：A ‘Clicked’ Tetrameric Hydroxamic Acid Glycopeptidomimetic Antagonizes Sugar-Lectin Interactions On The Cellular Level
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作者：Hai-Lin Zhang ; Yi Zang ; Juan Xie 等
期刊名称：Scientific Reports
电子版ISSN：2045-2322
出版年度：2014
卷号：4
DOI：10.1038/srep05513
出版社：Springer Nature
摘要：A tetrameric N -acetyl galactosaminyl (GalNAc) peptidomimetic was constructed by N -acetylation of repeating proline-based hydroxamic acid units, followed by a convergent ‘click chemistry’ coupling. This novel glycopeptidomimetic was determined to effectively antagonize the interaction between a transmembrane hepatic lectin and GalNAc on the cellular level.