文章基本信息

标题：Predominant Role of Cytosolic Phospholipase A₂α in Dioxin-induced Neonatal Hydronephrosis in Mice
本地全文：下载
作者：Wataru Yoshioka ; Tatsuya Kawaguchi ; Nozomi Fujisawa 等
期刊名称：Scientific Reports
电子版ISSN：2045-2322
出版年度：2014
卷号：4
DOI：10.1038/srep04042
出版社：Springer Nature
摘要：Hydronephrosis is a common disease characterized by dilation of the renal pelvis and calices, resulting in loss of kidney function in the most severe cases. 2,3,7,8-Tetrachlorodibenzo- p -dioxin (TCDD) induces nonobstructive hydronephrosis in mouse neonates through upregulation of prostaglandin E₂ (PGE₂) synthesis pathway consisting of cyclooxygenase-2 (COX-2) and microsomal prostaglandin E synthase-1 (mPGES-1) by a yet unknown mechanism. We here studied possible involvement of cytosolic phospholipase A₂α (cPLA₂α) in this mechanism. To this end, we used a cPLA₂α-null mouse model and found that cPLA₂α has a significant role in the upregulation of the PGE₂ synthesis pathway through a noncanonical pathway of aryl hydrocarbon receptor. This study is the first to demonstrate the predominant role of cPLA₂α in hydronephrosis. Elucidation of the pathway leading to the onset of hydronephrosis using the TCDD-exposed mouse model will deepen our understanding of the molecular basis of nonobstructive hydronephrosis in humans.