文章基本信息

标题：Temperature alters Plasmodium blocking by Wolbachia
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作者：Courtney C. Murdock ; Simon Blanford ; Grant L. Hughes 等
期刊名称：Scientific Reports
电子版ISSN：2045-2322
出版年度：2014
卷号：4
DOI：10.1038/srep03932
出版社：Springer Nature
摘要：Very recently, the Asian malaria vector ( Anopheles stephensi ) was stably transinfected with the w AlbB strain of Wolbachia , inducing refractoriness to the human malaria parasite Plasmodium falciparum . However, conditions in the field can differ substantially from those in the laboratory. We use the rodent malaria P. yoelii , and somatically transinfected An. stephensi as a model system to investigate whether the transmission blocking potential of w AlbB is likely to be robust across different thermal environments. w AlbB reduced malaria parasite prevalence and oocyst intensity at 28°C. At 24°C there was no effect on prevalence but a marked increase in oocyst intensity. At 20°C, w AlbB had no effect on prevalence or intensity. Additionally, we identified a novel effect of w AlbB that resulted in reduced sporozoite development across temperatures, counterbalancing the oocyst enhancement at 24°C. Our results demonstrate complex effects of temperature on the Wolbachia -malaria interaction, and suggest the impacts of transinfection might vary across diverse environments.