文章基本信息

标题：Nd³⁺ Sensitized Up/Down Converting Dual-Mode Nanomaterials for Efficient In-vitro and In-vivo Bioimaging Excited at 800 nm
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作者：Xiaomin Li ; Rui Wang ; Fan Zhang 等
期刊名称：Scientific Reports
电子版ISSN：2045-2322
出版年度：2013
卷号：3
DOI：10.1038/srep03536
出版社：Springer Nature
摘要：Core/shell1/shell2/shell3 structured NaGdF₄:Nd/NaYF₄/NaGdF₄:Nd,Yb,Er/NaYF₄ nanocrystals were well designed and synthesized, each of the parts assume respective role and work together to achieve dual-mode upconverting (UC) and downconverting (DC) luminescence upon the low heat effect 800-nm excitation. Nd³⁺, Yb³⁺, Er³⁺ tri-doped NaGdF₄:Nd,Yb,Er UC layer [NIR (800 nm)-to-Visible (540 nm)] with a constitutional efficient 800 nm excitable property were achieved for the in-vitro bioimaging with low auto-fluorescence and photo-damage effects. Moreover, typical NIR (800 nm)-to-NIR (860–895 nm) DC luminescence of Nd³⁺ has also been realized with this designed nanostructure. Due to the low heat effect, high penetration depth of the excitation and the high efficiency of the DC luminescence, the in-vivo high contrast DC imaging of a whole body nude mouse was achieved. We believe that such dual-mode luminescence NCs will open the door to engineering the excitation and emission wavelengths of NCs and will provide a new tool for a wide variety of applications in the fields of bioanalysis and biomedical.