文章基本信息

标题：ArCH(OMe)₂ - a Pt^IV-catalyst originator for diverse annulation catalysis
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作者：Subhadeep Ghosh ; Saikat Khamarui ; Krishnanka S. Gayen 等
期刊名称：Scientific Reports
电子版ISSN：2045-2322
出版年度：2013
卷号：3
DOI：10.1038/srep02987
出版社：Springer Nature
摘要：We discover an important property of a small molecule ArCH(OMe)₂ which transforms catalytically inactive Pt^IIBr₂ procatalyst in situ to an powerful catalyst Pt^IV-species for diverse annulation reaction. The powerful catalytic system enables selective activation of C₂-H/N-H and C₂-H/C₄-H of acetoacetanilide and C = O/C≡C of substituted butyne-1,2-dione for C-C/C-N, C-C/C-C and C-O/C-O bond-forming inter- and intramolecular annulation towards direct syntheses of functionalised 2-pyridones, cyclohexenones and 3(2 H )-furanones respectively. In contrast to the common ligand, herein highly labile C-OMe bond of ArCH(OMe)₂ is expected to react with PtBr₂ towards generation of the high-valent active catalyst. Unlike catalyst promoter or initiator, the reaction does not occur with PtBr₂ in the absence of ArCH(OMe)₂. In situ generation of Pt^IV-species and -OMe fragment of ArCH(OMe)₂ were confirmed from the UV-vis characteristic peaks about 260 nm and trapping of -OMe group respectively. These observations provide new prospects and perspectives in catalysis for innovative catalyst design.