文章基本信息

标题：Prostaglandin E₂ is critical for the development of niacin-deficiency-induced photosensitivity via ROS production
本地全文：下载
作者：Kazunari Sugita ; Atsuko Ikenouchi-Sugita ; Yasuko Nakayama 等
期刊名称：Scientific Reports
电子版ISSN：2045-2322
出版年度：2013
卷号：3
DOI：10.1038/srep02973
出版社：Springer Nature
摘要：Pellagra is a photosensitivity syndrome characterized by three “D's”: diarrhea, dermatitis, and dementia as a result of niacin deficiency. However, the molecular mechanisms of photosensitivity dermatitis, the hallmark abnormality of this syndrome, remain unclear. We prepared niacin deficient mice in order to develop a murine model of pellagra. Niacin deficiency induced photosensitivity and severe diarrhea with weight loss. In addition, niacin deficient mice exhibited elevated expressions of COX-2 and PGE syntheses ( Ptges ) mRNA. Consistently, photosensitivity was alleviated by a COX inhibitor, deficiency of Ptges , or blockade of EP4 receptor signaling. Moreover, enhanced PGE₂ production in niacin deficiency was mediated via ROS production in keratinocytes. In line with the above murine findings, human skin lesions of pellagra patients confirmed the enhanced expression of Ptges . Niacin deficiency-induced photosensitivity was mediated through EP4 signaling in response to increased PGE₂ production via induction of ROS formation.