文章基本信息

标题：Mn₃[Co(CN)₆]₂@SiO₂ Core-shell Nanocubes: Novel bimodal contrast agents for MRI and optical imaging
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作者：Yimin Huang ; Lin Hu ; Tingting Zhang 等
期刊名称：Scientific Reports
电子版ISSN：2045-2322
出版年度：2013
卷号：3
DOI：10.1038/srep02647
出版社：Springer Nature
摘要：Nanoprobes with dual modal imaging of magnetic resonance imaging (MRI) and two-photon fluorescence (TPF) can serve as promising platforms for clinical diagnosis. A wide range of molecules and nanoparticles have been investigated as agents for contrast enhanced MRI and fluorescence imaging in cancer diagnosis. However, a single material with dual modal imaging of MRI and TPF is rarely reported. We found that Mn₃[Co(CN)₆]₂ nanocubes can serve as agents for both T₁- and T₂-weighted MRI, and TPF imaging. The nanocubes coated with silica to form Mn₃[Co(CN)₆]₂@SiO₂ core-shell nanocubes were readily internalized by cells without showing cytotoxicity. In vitro tests, the core-shell nanocubes display relatively high longitudinal (r₁) and transverse (r₂) relaxivities, they also manifest a remarkable T₁ and T₂ contrast effects at in-vivo imaging of internal organs in Mice. Moreover, the core-shell nanocubes could offer high-resolution cell fluorescence imaging by two-photon excitation (720 nm) or by conventional fluorescence with 403- or 488-nm excitation.