文章基本信息

标题：Topological insulator bismuth selenide as a theranostic platform for simultaneous cancer imaging and therapy
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作者：Juan Li ; Fei Jiang ; Bo Yang 等
期刊名称：Scientific Reports
电子版ISSN：2045-2322
出版年度：2013
卷号：3
DOI：10.1038/srep01998
出版社：Springer Nature
摘要：Employing theranostic nanoparticles, which combine both therapeutic and diagnostic capabilities in one dose, has promise to propel the biomedical field toward personalized medicine. Here we investigate the theranostic properties of topological insulator bismuth selenide (Bi₂Se₃) in in vivo and in vitro system for the first time. We show that Bi₂Se₃ nanoplates can absorb near-infrared (NIR) laser light and effectively convert laser energy into heat. Such photothermal conversion property may be due to the unique physical properties of topological insulators. Furthermore, localized and irreversible photothermal ablation of tumors in the mouse model is successfully achieved by using Bi₂Se₃ nanoplates and NIR laser irradiation. In addition, we also demonstrate that Bi₂Se₃ nanoplates exhibit strong X-ray attenuation and can be utilized for enhanced X-ray computed tomography imaging of tumor tissue in vivo. This study highlights Bi₂Se₃ nanoplates could serve as a promising platform for cancer diagnosis and therapy.