文章基本信息

标题：IL-6 activated integrated BATF/IRF4 functions in lymphocytes are T-bet-independent and reversed by subcutaneous immunotherapy
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作者：Sonja Koch ; Stephanie Mousset ; Anna Graser 等
期刊名称：Scientific Reports
电子版ISSN：2045-2322
出版年度：2013
卷号：3
DOI：10.1038/srep01754
出版社：Springer Nature
摘要：IL-6 plays a central role in supporting pathological T_H2 and T_H17 cell development and inhibiting the protective T regulatory cells in allergic asthma. T_H17 cells have been demonstrated to regulate allergic asthma in general and T-bet-deficiency-induced asthma in particular. Here we found an inverse correlation between T-bet and Il-6 mRNA expression in asthmatic children. Moreover, experimental subcutaneous immunotherapy (SIT) in T-bet^(−/−) mice inhibited IL-6, IL-21R and lung T_H17 cells in a setting of asthma. Finally, local delivery of an anti-IL-6R antibody in T-bet^(−/−) mice resulted in the resolution of this allergic trait. Noteworthy, BATF, crucial for the immunoglobulin-class-switch and T_H2,T_H17 development, was found down-regulated in the lungs of T-bet^(−/−) mice after SIT and after treatment with anti-IL-6R antibody, indicating a critical role of IL-6 in controlling BATF/IRF4 integrated functions in T_H2, T_H17 cells and B cells also in a T-bet independent fashion in allergic asthma.