文章基本信息

标题：Anti-Androgenic Activity of Icarisid II from Epimedium Herb in Prostate Cancer LNCaP Cells
本地全文：下载
作者：Yoko MIURA ; Masayoshi OYAMA ; Kazuhiro IGUCHI 等
期刊名称：Journal of Nutritional Science and Vitaminology
印刷版ISSN：0301-4800
电子版ISSN：1881-7742
出版年度：2015
卷号：61
期号：2
页码：201-204
DOI：10.3177/jnsv.61.201
出版社：Center for Academic Publications Japan
摘要：Anti-androgens are regarded as potential therapeutic agents for the treatment of prostate cancer. We determined that an epimedium herb (EH) extract exhibited anti-androgenic activity in a luciferase assay using androgen receptor-positive prostate cancer LNCaP cells. Nine EH-derived flavonoids were examined. The results identified icarisid II as a very potent anti-androgenic EH-derived flavonoid. A quantitative RT-PCR analysis confirmed that the flavonol suppressed the expression of the androgen-responsive KLK3 gene.
关键词：epimedium herb;anti-androgenic activity;icarisid II;flavonoid glycoside