文章基本信息

标题：Vitamin A Deficiency Impairs Induction of Oral Tolerance in Mice
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作者：Akiko NAKAMOTO ; Emi SHUTO ; Rie TSUTSUMI 等
期刊名称：Journal of Nutritional Science and Vitaminology
印刷版ISSN：0301-4800
电子版ISSN：1881-7742
出版年度：2015
卷号：61
期号：2
页码：147-153
DOI：10.3177/jnsv.61.147
出版社：Center for Academic Publications Japan
摘要：Oral tolerance is a phenomenon of induction of systemic unresponsiveness to antigens ingested by the oral route and loss of immune response. Studies have shown the importance of vitamin A in oral tolerance in vitro but not in an in vivo experimental model. Therefore, we carried out experiments to determine how vitamin A deficiency affects tolerance induction and the ability of mesenteric lymph node (MLN) CD11c⁺ cells to induce regulatory T cells (Tregs). Immunological tolerance was induced by oral ovalbumin (OVA) administration in vitamin A-sufficient mice. OVA-specific antibody and cytokine production were significantly reduced. On the other hand, in vitamin A-deficient mice, both OVA-specific antibody and cytokine production were not suppressed by oral OVA administration. Regarding induction of Tregs, the conversion rate of Foxp3⁺ cells from naïve CD4⁺ cell by CD11c⁺ cells was decreased in vitamin A-deficient mice. Our study indicates that vitamin A deficiency causes the breakdown of oral tolerance in vivo.
关键词：oral tolerance;vitamin A deficiency;regulatory T cells;CD11c+ cells;antibody