文章基本信息

标题：Is the serum L-arginine level during early pregnancy a predictor of pregnancy-induced hypertension?
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作者：Jingwen Wang ; Tomomi Kotani ; Hiroyuki Tsuda 等
期刊名称：Journal of Clinical Biochemistry and Nutrition
印刷版ISSN：0912-0009
电子版ISSN：1880-5086
出版年度：2015
卷号：57
期号：1
页码：74-81
DOI：10.3164/jcbn.14-104
出版社：The Society for Free Radical Research Japan
摘要：The objective of this study was to determine the concentration of serum l -arginine in healthy pregnant women and infant cord blood and to compare them with those in patients with pregnancy-induced hypertension (PIH). The serum concentration of l -arginine in normal pregnant women at early gestation ( n = 186) was determined and analyzed based on maternal factors such as the age, pre-pregnancy body mass index (BMI), smoking and alcohol habits before pregnancy. Similarly, the concentration of cord blood of the newborns ( n = 142) was also analyzed. These values were compared with those in the PIH group ( n = 21). The potential risk factors for PIH were also estimated. The serum concentration of l -arginine at early gestation in normal pregnant women (88.65 ± 19.96 µM) was not affected by the maternal age and BMI before pregnancy. A lower l -arginine concentration at early gestation (<70 µM) significantly elevated PIH risk [adjusted odds ratio (OR) = 4.26, 95% CI 1.29–14.50]. In addition, either women with large body mass before pregnancy (BMI>25 kg/m²) or primipara women also showed a significant association with PIH risk [adjusted OR = 10.55 (2.95–40.68); 5.25 (1.72–19.15), respectively]. In conclusion, a lower l -arginine concentration at early gestation, overweight before pregnancy (BMI>25 kg/m²) and primipara could predict to the development of PIH.
关键词：L-arginine;pregnancy-induced hypertension;parity;cord blood