文章基本信息

标题：Effect of higher frequency components and duration of vibration on bone tissue alterations in the rat-tail model
本地全文：下载
作者：Srikara V. PEELUKHANA ; Shilpi GOENKA ; Brian KIM 等
期刊名称：Industrial Health
印刷版ISSN：0019-8366
电子版ISSN：1880-8026
出版年度：2015
卷号：53
期号：3
页码：245-259
DOI：10.2486/indhealth.2014-0117
出版社：National Institute of Occupational Safety and Health
摘要：To formulate more accurate guidelines for musculoskeletal disorders (MSD) linked to Hand-Arm Vibration Syndrome (HAVS), delineation of the response of bone tissue under different frequencies and duration of vibration needs elucidation. Rat-tails were vibrated at 125 Hz (9 rats) and 250 Hz (9 rats), at 49 m/s², for 1D (6 rats), 5D (6 rats) and 20D (6 rats); D=days (4 h/d). Rats in the control group (6 rats for the vibration groups; 2 each for 1D, 5D, and 20D) were left in their cages, without being subjected to any vibration. Structural and biochemical damages were quantified using empty lacunae count and nitrotyrosine signal-intensity, respectively. One-way repeated-measure mixed-model ANOVA at p <0.05 level of significance was used for analysis. In the cortical bone, structural damage quantified through empty lacunae count was significant ( p <0.05) at 250 Hz (10.82 ± 0.66) in comparison to the control group (7.41 ± 0.76). The biochemical damage was significant ( p <0.05) at both the 125 Hz and 250 Hz vibration frequencies. The structural damage was significant ( p <0.05) at 5D for cortical bone while the trabecular bone showed significant ( p <0.05) damage at 20D time point. Further, the biochemical damage increased with increase in the duration of vibration with a significant ( p <0.05) damage observed at 20D time point and a near significant change ( p =0.08) observed at 5D time point. Structural and biochemical changes in bone tissue are dependent upon higher vibration frequencies of 125 Hz, 250 Hz and the duration of vibration (5D, 20D).
关键词：Hand-arm vibration syndrome;Resonance frequency;Osteocyte;Biochemical alterations;Nitrotyrosine