The research aim was to predict the bus operators’ blood pressure (BP) and psychological strain using a combination of the Job-Demand Control (JDC) and Effort-Reward Imbalance (ERI) models. The study was conducted with a sample of 139 bus operators in the city of Bogotá (Colombia), who answered a questionnaire that included the Job Content Questionnaire (JCQ), the ERI Questionnaire, and the General Health Questionnaire (GHQ). Four consecutive BP readings taken in the workplace were averaged to calculate an estimation of the bus operators’ BP. By conducting multiple linear regressions it was found that, taken together, JDC and ERI models explain 10% (F_(11,139)=2,502; p =0.00) of systolic BP variance, and 34% (F_(6,139)=8,638; p =0.00) of psychological strain variance. These results suggest that the JDC and ERI predictors provide complementary information which increases the probability of accurately model the bus operators’ health.