文章基本信息

标题：Detecting Protein Complexes through Micro-Network Comparison in Protein-Protein Interaction Networks
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作者：Li, Haihong ; Zhong, Luo ; Yao, Huaxiong 等
期刊名称：Journal of Networks
印刷版ISSN：1796-2056
出版年度：2013
卷号：8
期号：3
页码：696-703
DOI：10.4304/jnw.8.3.696-703
语种：English
出版社：Academy Publisher
摘要：Proteins are likely to form closely coupled protein complexes as functional units to participate in biological processes. We propose a Micro-Network Comparison algorithm to solve the problem of detecting protein complexes from protein interaction networks. We express the characters of a connection between a node and a core graph through the In-module Micro-network graph and Out-module Micro-network graph. We compare the number of edges in two graphs to decide whether a node has a dense or loose connection to a core graph. We give four experimental results using the algorithm and the results show that our algorithm has an excellent performance in both accuracy and hit rate.
关键词：protein complexes;protein interaction networks;Micro-Network Comparison;PPI