文章基本信息

标题：Improved Thrombin Hemostat Using the Cross-Linked Gelatin by Microbial Transglutaminase
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作者：Tengfei Yu ; Yuepeng Guan ; Xia Xie 等
期刊名称：International Journal of Polymer Science
印刷版ISSN：1687-9422
电子版ISSN：1687-9430
出版年度：2015
卷号：2015
DOI：10.1155/2015/985286
出版社：Hindawi Publishing Corporation
摘要：It is well known that the thrombin obtained from animal is available in clinical treatment, which plays an important role in hemostasis and the treatment of hemorrhagic diseases. However, how to achieve complete hemostasis in 2 min is still a challenge. In this report, the thrombin hemostatic has been improved using the cross-linked gelatin by microbial transglutaminase, and its efficacy was demonstrated by the vitro experiment. Compared with the traditional thrombin hemostatic the clotting time with the improved hemostat is significantly shorter. It may rapidly stop blood loss, which would provide a simple, safe, and cost-effective surgical sealant.