文章基本信息

标题：Local Angiotensin Pathways in Human Carotid Atheroma: Towards a Systems Biology Approach
本地全文：下载
作者：Giampiero Bricca ; Liliana Legedz ; Ali Nehme 等
期刊名称：Conference Papers in Science
印刷版ISSN：2356-6108
出版年度：2015
卷号：2015
DOI：10.1155/2015/593086
出版社：Hindawi Publishing Corporation
摘要：We will summarize the data we have obtained in human carotid artery concerning the organization of an extended local renin angiotensin aldosterone system and its variations at different stages of atheroma. In a system view, we propose a model where concomitant increase in angiotensin and glucocorticoid signaling is induced and amplified in VSMC while vascular smooth muscle cells transdifferentiate toward a lipid storing phenotype.