文章基本信息

标题：The role of regulatory T cells in cancer immunology
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作者：Theresa L Whiteside
期刊名称：ImmunoTargets and Therapy
电子版ISSN：2253-1556
出版年度：2015
卷号：4
页码：159-171
DOI：10.2147/ITT.S55415
出版社：Dove Medical Press Ltd
摘要：Regulatory T cells (Treg) are generally considered to be significant contributors to tumor escape from the host immune system. Emerging evidence suggests, however, that in some human cancers, Treg are necessary to control chronic inflammation, prevent tissue damage, and limit inflammation-associated cancer development. The dual role of Treg in cancer and underpinnings of Treg diversity are not well understood. This review attempts to provide insights into the importance of Treg subsets in cancer development and its progression. It also considers the role of Treg as potential biomarkers of clinical outcome in cancer. The strategies for monitoring Treg in cancer patients are discussed as is the need for caution in the use of therapies which indiscriminately ablate Treg. A greater understanding of molecular pathways operating in various tumor microenvironments is necessary for defining the Treg impact on cancer and for selecting immunotherapies targeting Treg.
关键词：cancer; regulatory T cells; tumor microenvironment; immune suppression; anti-Treg therapies