文章基本信息

标题：Detection of boldenone, its sulfate and glucuronate forms, androstadienedione, cortisol, cortisone, prednisolone, prednisone and dexamethasone in bovine bile and urine by LC-MS/MS: preliminary results.
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作者：Maria Nobile ; Luca Chiesa ; Radmila Pavlovic 等
期刊名称：International Journal of Health, Animal Science and Food Safety
印刷版ISSN：2283-3927
出版年度：2015
卷号：2
期号：1s
DOI：10.13130/2283-3927/5006
语种：English
出版社：Department of Health, Animal Science and Food Safety (VESPA)
摘要：The European Union regulations ban or regulate the use of substances with hormonal action. There are, however, some detectable steroids in biological matrices from cattle to which no administration were made. These are the so called “grey-zone” or “pseudoendogenous” substances (endogenously produced under certain circumstances). The administration of boldenone and androstadienedione to cattle is forbidden both for therapeutic or growth promotion purposes, while therapeutic use of prednisolone is permitted. The control of the use of these substances is hampered by their pseudoendogenous nature. We made a comparison between analyses performed on the classical matrix urine with bile (a novel matrix) from the same animals, with the aim to determine the better matrix for the above mentioned steroids. We tested the synthetic corticosteroid dexamethasone, too. The preliminary results do not show any difference between the two matrices, as concern the pseudoendogenous substances. The data about dexamethasone were instead very promising about the use of bile. The detection frequency and concentration levels were, in fact, higher in bile than in urine from the same animals.
关键词：pseudoendogenous steroids;bile;LC-MS/MS