期刊名称：Walailak Journal of Science and Technology (WJST)
印刷版ISSN：2228-835X
出版年度：2015
卷号：13
期号：3
DOI：10.14456/vol13iss6pp%p
语种：English
出版社：Institute of Research and Development, Walailak University.
摘要：Overproduction of melanin pigment is well recognized with hyperpigmentation disorders and melanoma progression. This study we investigated anti-oxidant activities of oxyresveratrol from Artocarpus lakoocha Roxb. The effects of oxyresveratrol on melanogenesis, tyrosinase activity, and cellular oxidants in B16 cells were also obtained. Toxic doses of oxyresveratrol were confirmed by using in vitro micronucleus method in V79 cells. Oxyresveratrol had a potent anti-oxidant activity. It also showed a statistical significance to inhibit melanogenesis, tyrosinase activity, and cellular oxidants in B16 cells at 10 and 12.5 mg/ml. These effective doses had no toxicity in V79 cells. Oxyresveratrol had a potent to inhibit melanogenesis in B16 cells through the role of cellular oxidants relating tyrosinase activity. The effective doses of this agent may be used to control hyperpigmentation disorders and applied in chemopreventive drug for melanoma.
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