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标题：Cristalización de proteínas en el diseño de fármacos en los últimos 50 años
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作者：Enrico A. Stura
期刊名称：Arbor
印刷版ISSN：1988-303X
出版年度：2015
卷号：191
期号：772
页码：222
DOI：10.3989/arbor.2015.772n2008
语种：English
出版社：Consejo Superior de Investigaciones Científicas
摘要：We live in an era where we expect to be able to visit our doctor and obtain a pill to cure any ailment from which we suffer. Yet, this is still not the case. Many of the current cures are still derived from natural sources although new drugs are increasingly the result of intelligent design. In this process, X-ray protein crystallography now plays a major and effective role in the discovery of new treatments. The developments that have made this possible have evolved during the past fifty years. The methods for crystallizing macromolecules and determining their structures by X-ray crystallography have been automated and the speed for X-ray data acquisition is several orders of magnitude faster. Fifty years ago it took several years to solve a single structure. Now, several protein–ligand complexes can be determined in single day. High-throughput crystallography is considered to be a great asset to the drug discovery process, providing a fast way to tailor drug candidates to their targets by analysing their binding mode in detail. Crystallization remains the main challenge.
关键词：Drug design;crystallization;diseño de fármacos;cristalización