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标题：Fluoxetina reduziu a polidipsia e a pressão à barra sem reduzir atividade motora
其他标题：Fluoxetine reduced polydipsia and bar pressing without reducing motor activity
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作者：Machado Santarem, Érica Maria ; Alvares Toscano, Cláudia ; Araujo Silva, Maria Teresa 等
期刊名称：Acta Comportamentalia: Revista Latina de Análisis del Comportamiento
印刷版ISSN：0188-8145
出版年度：2010
卷号：12
期号：2
语种：Portuguese
出版社：Acta Comportamentalia: Revista Latina de Análisis del Comportamiento
摘要：A fluoxetina (FLX) é um inibidor seletivo de receptação de serotonina utilizado no tratamento do transtorno obsessivo-compulsivo (TOC). O objetivo deste trabalho foi verificar se o efeito da FLX sobre a polidipsia induzida pelo esquema poderia ser explícada por um prejuízo motor. A polidipsia foi induzidaem ratos por um esquema de FI 60 s. AFLX ou veículo foi injetada i.p. por 28 dias na dose de 5 rnglkg e em seguida por 21 dias na dose de 10 mg/kg. Registraram-se: volume de água ingerida, respostas de pressão à barra. e os comportamentos observadosde Locomover-se, Erguer-se e Farejar. A FLXdiminuiu a polidipsia e a taxa de respostas em FI na dose de 10mg, sem diminuir a freqüênciado Locomover-se,do Erguer-se e do Farejar. Concluiu-seque o efeito da FLX sobre a polidipsia induzida por esquema independe de um efeito motor. Os resultados podem ser atribuidos à ação anti-compulsiva da FLX ou à diminuição do valor reforçador do alimento pela ação anoréxica da droga.Nos dois casos, os resultados estão de acordo com a hipótese de que os comportamentos induzido e operante são controlados pelas mesmas variáveis e compartilham a mesma natureza.
其他摘要：Fluoxetine (FLX) is a selective serotonin reuptake inhibitor which is used, among other, for the treatment of obsessive-compulsive disorder (OCD). FLX has been shown to decrease schedule- induced polydipsia, and is considered an animal model for obsessive-compulsive disorder. The aim of the present research was to verify whether FLX-induced reduction of polydipsia could be explained by a motor deficit caused by the drug. Polydipsia was induced in rats pressing a lever on a fixed interval 60s (F1 60) schedule of food reinforcement. Daily 32 min baseline sessions were conducted until stable polydipsic behavior was obtained in 16 subjects with daily water intake between 10 and 15 ml. subjects were then given either 5 mg/kg FLX (N=8) i.p. injections during 28 days, followed by 10 mg/kg FLX or vehicle injections during 21 days. During treatment experimental sessions were run once a week behavior observation was registered according to defined categories on the last baseline F1 session and the last FLX 5 mg and FLX 10 mg sessions. The following measures were taken: volume of water drunk, frequency of lever- pressing responses, and observed responses in the locomotion, rearing and sniffing categories. FLX reduced both polydipsia and F1 response rate at 10 mg/kg, but did not alter locomotion and rearing. Sniffing was significantly increased at both drug dosages. It was concluded that FLX affect on schedule induced polydipsia is independent of motor effects. The simultaneous reductions of induced drinking and response rate can be attributed either to the anti-compulsive action of FLX or to the reduction in the reinforcing value of food due to the anorexic effect of the drug. Whatever the interpretation, the results agree with the hypothesis that operant and induced behavior are controlled by the same variables and share a common nature.
关键词：fluoxetina; polidipsia; atividade motora; comportamento operante; comportamento induzido; comportamento adjunto; beber; pressão à barra; ratos.
其他关键词：Fluoxetine; polydipsia; motor activity; operant behavior; schedule-induced behavior; adjunctive behavior; drinking; bar pressing; rats.