文章基本信息

标题：A misdiagnosed myasthenia gravis with anti-muscle-specific tyrosine kinase antibodies with possible childhood onset
本地全文：下载
作者：Nikolić, Ana V. ; Lavrnić, Dragana V. ; Basta, Ivana Z. 等
期刊名称：Vojnosanitetski pregled
印刷版ISSN：0042-8450
出版年度：2015
卷号：72
期号：7
页码：639-641
DOI：10.2298/VSP131111039N
出版社：Military Medical Academy, INI
摘要：Introduction. Childhood onset myasthenia gravis associated with anti-muscle-specific tyrosine kinase antibodies is very rare and atypical in presentation. Case report. As a baby, the pre-sented patient was choking and sleeping with open eyes. She had weak cry and breathing difficulties. In childhood, there were frequent falls and fluctuating swallowing difficulties. At the age of 19 she was misdiagnosed with Miller Fisher syndrome due to the presence of diplopia, ataxia and hyporeflexia with spontaneous recovery. Repetitive nerve stimulation test was normal. Four years later, after several relapses, there was significant decrement on facial muscles. Neostigmine test was negative, provoking muscle fasciculations. Serum anti-muscle-specific tyrosine kinase antibodies were positive. With cyclosporine therapy she achieved the minimal manifestations status. Conclusion. The presented case confirms that childhood onset myasthenia gravis associated with anti-muscle-specific tyrosine kinase antibodies is often with atypical presentation and spontaneous remissions, so it could be easily misdiagnosed.
关键词：myasthenia gravis; child; diagnosis; differential; antibodies; protein-tyrosine kinases