By using a sequence analysis of 16S rRNA clone libraries, the whole stracture of human gut microbiota has emerged. A profile of human gut microbiota with terminal restriction fragment length polymorphism analysis was used to characterize and compare gut microbiota in individuals. A differential profile comparing gut microbiota between health and disease were noted. Probiotics are live microbial food ingradients that have a beneficial effect on human health. It will be of particular value to have good prospective evidence that links the habitual intake of a specified probiotic component with subsequent disease risk and control.