文章基本信息

标题：Evolutionary Ecology and Control of Infectious Disease Virulence
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作者：Koh-Ichi TAKAKURA
期刊名称：生活衛生
印刷版ISSN：0582-4176
电子版ISSN：1883-6631
出版年度：2009
卷号：53
期号：3
页码：145-152
DOI：10.11468/seikatsueisei.53.145
出版社：Osaka Urban Living and Health Association
摘要：Recently, there have been fears that an influenza pandemic is approaching in the near future and the importance of preventing infection has often been discussed. The possibility of controlling the evolution of virulence has however received less attention. In the present paper, I first introduce the evolutionary ecology of infectious disease virulence based on the existing theoretical work and then explain three possible selection pressures that favor very serious virulence and suggest promising methods to reduce the effect of each. Most of these methods are consistent with methods to prevent the spread of infection, while one also emphasizes the importance of international cooperation in the elimination of poverty and conflict. I suggest thus that evolutionary ecological thinking has the potential to provide a new point of view in the control of infectious diseases.
关键词：evolutionary ecology;superinfection;tragedy of the commons;transmission rate;virulence