文章基本信息

标题：Methods for Rapid Detection of Drug Resistant Mycobacterium tuberculosis
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作者：Takayuki WADA
期刊名称：生活衛生
印刷版ISSN：0582-4176
电子版ISSN：1883-6631
出版年度：2007
卷号：51
期号：3
页码：141-148
DOI：10.11468/seikatsueisei.51.141
出版社：Osaka Urban Living and Health Association
摘要：Drug-resistant tuberculosis (TB) has been increasing worldwide. It is important to identify drug-resistance in bacilli rapidly to suppress the spread of drug-resistant TB. The currently available drug-susceptibility testing methods can be classified according to two strategies: 1) culture of bacilli on testing media including anti-tubercular agents to check their viability; and 2) detection of mutations relative to drug-resistant phenotypes of Mycobacterium tuberculosis . Here, we summarize the relationships between drug-resistance and genes of M. tuberculosis . We also present a rapid detection system for drug-resistant TB using real-time PCR. This method is simple, rapid, and accurate, and can therefore be applied to detect drug-resistant M. tuberculosis in clinical laboratories.
关键词：Drug-Resistance;Tuberculosis;Multidrug-Resistant;Antitubercular Agents;Microbial Sensitivity Tests