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标题：Contact Allergenicity and Cross Reactivity of 2,3,5,6-Tetrachloro-4-(methylsulfonyl)pyridine in Guinea Pig Maximization Test
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作者：Tsutomu NODA ; Tetsuo YAMANO ; Tomoko OOSHIMA 等
期刊名称：生活衛生
印刷版ISSN：0582-4176
电子版ISSN：1883-6631
出版年度：2006
卷号：50
期号：2
页码：76-83
DOI：10.11468/seikatsueisei.50.76
出版社：Osaka Urban Living and Health Association
摘要：The contact sensitizing potentials and cross reactivity patterns of 2,3,5,6-tetrachloro-4-(methylsulfonyl)pyridine (TCMSP) were evaluated in a modified guinea pig maximization test (GPMT). TCMSP was identified as a strong sensitizer in the GPMT with a minimum induction dose of 5 ppm, and a minimum elicitation dose of 50 ppm or less. Among pyridine derivatives tested, TCMSP-sensitized animals cross-reacted to pentachloropyridine. In addition, the animals reacted to 2,4,5,6-tetrachloroisophthalonitrile, a chlorobenzene derivative. Pentachloropyridine exhibited a sensitization potential in the GPMT, and cross-reacted to both TCMSP and 2,4,5,6-tetrachloroisophthalonitrile.
关键词：2,3,5,6-tetrachloro-4-(methylsulfonyl)pyridine;pentachloropyridine;2,4,5,6-tetrachloroisophthalonitrile;skin sensitization;guinea pig maximization test