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标题：The Effect of Synthetic Agonists and Antagonists of Cannabinoid Receptors on Migration of Neutrophils Elicited by Leukotriene B₄ in the Microvasculature of Hamster Cheek Pouch
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作者：Eri Nakahara ; Yoshihiro Nara ; Akiko Ozawa 等
期刊名称：循環制御
印刷版ISSN：0389-1844
出版年度：2010
卷号：31
期号：3
页码：202-207
DOI：10.11312/ccm.31.202
出版社：Japan Society of Circulation Control in Medicine
摘要：This study was designed to investigate the effects of cannabinoid agonists and antagonists on neutrophil behaviors in response to inflammatory stimulation. The neutrophil behavior was observed in the microvasculature of hamster cheek pouch using a trans-illumination microscope. Superfusion of leukotriene B₄ caused an increase in the number of neutrophils migrating through the endothelium outside the venules. The migration induced by leukotriene B₄ was significantly attenuated in hamsters receiving WIN55212-2, a synthetic non-selective cannabinoid agonist, prior to the leukotriene B₄ superfusion. The inhibitory effect of WIN55212-2 was abolished by AM251, a selective CB₁ antagonist, and also by AM630, a selective CB₂ antagonist. These results suggest that augmentation of the CB₁ and CB₂ cannabinoid system could produce the inhibition of neutrophil migration and contribute to suppression of inflammatory derangement.
关键词：cannabinoid ; neutrophil ; leukotriene B₄