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标题：Effects of Edaravone on Reperfusion-Induced Arrhythmias in the Isolated Rat Heart
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作者：Masayo Takami ; Kazuya Urashima ; Takako Nishihori 等
期刊名称：循環制御
印刷版ISSN：0389-1844
出版年度：2004
卷号：25
期号：3
页码：261-266
DOI：10.11312/ccm.25.261
出版社：Japan Society of Circulation Control in Medicine
摘要：The effects of edaravone on reperfusion-induced ventricular arrhythmias in the isolated perfused rat heart were investigated. Using Langendorff perfusion-system, each isolated rat heart was perfused with Krebs-Henseleit buffer, containing various concentrations of edaravone(0, 10, 25, 50, 75, 100, 150μM) for 10 minutes. After that, each heart was subjected to regional ischemia(11min) and reperfusion(3min). The result showed that edaravone had no significant effect on coronary flow and heart rate at any time during the experiment. At 25, 75, 100μM of edaravone, the incidence of reperfusion-induced ventricular fibrillation(VF) was significantly reduced from the control value(p<0.05). At 25μM of edaravone, the incidence of sustained VF was significantly reduced from 92% to 50%(p<0.05). Edaravone is suggested to have a protective effect against reperfusion-induced arrhythmias.
关键词：edaravone ; ischemia ; reperfusion ; arrhythmia ; free radical