文章基本信息

标题：The Study of Treatment for the Inhibition of Cardiac Function due to Levobupivacine
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作者：Kazuya Urashima ; Shiori Terai ; Takako Nishihori 等
期刊名称：循環制御
印刷版ISSN：0389-1844
出版年度：2004
卷号：25
期号：2
页码：169-175
DOI：10.11312/ccm.25.169
出版社：Japan Society of Circulation Control in Medicine
摘要：Levobupivacaine is a long acting, amide-type local anaesthetic that is the S(−)-isomer of the racemate bupivacaine. It has high affinity for the myocardial Na⁺ channel that can be cardiotoxic. So, an intravenous injection of levobupivacaine sometimes becomes a serious problem as the inhibition of cardiac function. Then, we investigated the effects of cardiac pacing and catecholamines(epinephrine, norepinephrine, isoproterenol) to treat the inhibition of cardiac function in isolated rat hearts. Our results showed that cardiac pacing and 0.8μg/kg/min epinephrine recovered the inhibition of cardiac function due to 5μg/ml levobupivacaine.
关键词：Levobupivacaine ; Bupivacaine ; Pacing ; Cardiac function ; Catecholamine