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标题：Potential of Hemodynamic Waveform Analysis to Detect Early-Stage Atherosclerotic Lesions of the Aorta
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作者：Hiroshi Miyashita ; Shin-ichiro Katsuda ; Tsuyoshi Shimizu 等
期刊名称：循環制御
印刷版ISSN：0389-1844
出版年度：2003
卷号：24
期号：4
页码：360-370
DOI：10.11312/ccm.24.360
出版社：Japan Society of Circulation Control in Medicine
摘要：Alterations in arterial properties detected by pulse wave velocity and pulse wave analyses in patients with hypercholesterolemia are controversial. Therefore, we used an animal model of atherosclerosis to test the potential of arterial mechanical properties indexed by aortic input impedance (Z_in) as markers for early detection of atheromatous lesions in the aorta. In 12-month-old anesthetized Kurosawa and Kusanagi-Hypercholesterolemic Rabbits (KHC; n=15), pressure and flow were measured at the ascending aorta during sinus rhythm and random pacing. We confirmed histologically in previous studies that early-stage atheromas developed in the aorta by this age. Age-matched Japanese White rabbits(JW;n=13) had no overt atheroma. High-resolution Z_in derived from random beating data was characterized by a lower ratio of the first local maximum to minimum |Z_in| (1.36±0.26 vs. 2.08±0.33; p<10^-5) accompanied by more delayed phases over a range between 6 and 8 Hz (−0.35±0.21 vs. −0.05±0.15 radian;p=0.0002); and a lower characteristic impedance (2.30±0.67 vs. 2.92±0.59 mmHg·s·kg BW/ ml ;p=0.016) in KHC than in JW rabbits. We concluded that frequency-specific changes in Z_in are sensitive hemodynamic markers that can detect early-stage atheromatous lesions in the aorta. High-resolution Z_in analysis is essential and useful for detecting such frequency-dependent findings.
关键词：Aortic input impedance ; Atherosclerosis ; Hyperlipidemia ; Aortic pressure ; Aortic flow