A new type of microperforated panel absorber (MPA) that has holes of multiple sizes instead of uniform size is experimentally investigated. The objective of this research is to obtain a wide band sound absorber that is thin, durable, clean, and healthy. The first step of this research is to investigate the performance of MPA having two different sizes and the same numbers of holes. The investigation is then extended to a combination of three and four different sizes of holes with various spatial arrangements and various densities or percentages of each size of holes on panels. The hole diameters vary between 0.4 mm and 1 mm and the cavity depths vary between 10 mm and 15 mm. The results show that a multi-size MPA enhances the absorption rate and widens the effective frequency band. This study also proves that a multi-size MPA when compared with a uniform size MPA has better sound absorption characteristics with respect to the absorber thickness and absorption bandwidth. These results make it possible to build thin, single layer sound absorbers that are effective in wide frequency bands and have the advantage of being tunable.