The purpose of this study was to clarify the kinetics of muscle oxygenation by near infrared spectroscopy (NIRS) in the phase of the decreasing force, especially the pre- and post-phases of the inflection point, during repeated rhythmic grip (RRG) of 30 grips/min⁻¹ for 6 minutes. The inflection point was the time at which the decreasing speed of the grip force changed markedly. It was calculated statistically from two regression lines fitted to each decreasing phase by applying a two-phase regression model. Ten healthy males performed the RRG for 6 minutes. Total Hb and Oxy-Hb decreased rapidly about 10 sec (7.0±5.9 sec, 9.8±5.4 sec, respectively) corresponding to the value decreasing by 90% MVC after the onset of gripping. Deoxy-Hb was maintained at a high value for 76.2±27.9 sec, corresponding to the value decreasing by 70–80% MVC. These phases are considered to be the states where oxygen was not satisfactorily supplied to the active muscles because of the obstruction of blood flow caused by an increase in the intra-muscular pressure. Deoxy-Hb decreased for 120±21.3 sec after reaching the highest value, and then reached an almost steady state at a higher level than the rest. After this phase, muscle oxygenation kinetics enters the state where oxygen is satisfactorily supplied to active muscles. We considered that the relationship between oxygen supply and demand differs during the initial and the latter phases in RRG. The changing phase in the decreasing speed of the grip force, namely the inflection point of the decreasing force, significantly correlated with the changing phase of the Oxy-Hb and Deoxy-Hb kinetics. The inflection point of the decreasing force seems to correspond to the phase where oxygen supply cannot meet oxygen demand and the increase of Deoxy-Hb. We infer that the pre- and post-phases of the inflection point depend on different physiological factors.