文章基本信息

标题：Longitudinal Changes in Pulmonary Function of Asbestos Workers
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作者：Xiaorong Wang ; Mianzhen Wang ; Hong Qiu 等
期刊名称：Journal of Occupational Health
印刷版ISSN：1341-9145
电子版ISSN：1348-9585
出版年度：2010
卷号：52
期号：5
页码：272-277
DOI：10.1539/joh.L10062
出版社：Japan Society for Occupational Health
摘要：Objective: To observe the longitudinal changes in pulmonary function associated with exposure to asbestos in a group of highly exposed workers. Methods: Pulmonary diffusing capacity (DLco) and spirometry of 243 Chinese asbestos workers were measured and remeasured after 5 and 10 yr. Their annual changes in relation to cumulative asbestos exposure and asbestosis were determined using multivariate analysis. Results: The greatest annual decline was observed in DLco, particularly in workers with asbestosis, followed by FVC and FEV₁. A greater decline in DLco accorded with a higher level of cumulative asbestos exposure. A similar trend was also seen in FVC, in which the highest exposure level was associated with 223 m l loss over each 5 yr period or 45 m l /yr. Conclusions: There were substantial declines in DLco and FVC over time in the asbestos workers, and a dose-response trend between asbestos exposure and accelerating functional loss.
关键词：Asbestosis;Asbestos workers;Longitudinal changes;Pulmonary diffusing capacity;Pulmonary function