文章基本信息

标题：Toxicity Study of the Volatile Constituents of Myoga Utilizing Acute Dermal Irritation Assays and the Guinea-Pig Maximization Test
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作者：Qingjun Wei ; Koichi Harada ; Shoko Ohmori 等
期刊名称：Journal of Occupational Health
印刷版ISSN：1341-9145
电子版ISSN：1348-9585
出版年度：2006
卷号：48
期号：6
页码：480-486
DOI：10.1539/joh.48.480
出版社：Japan Society for Occupational Health
摘要：Myoga is a fragrant plant which is the special product of Japan and is cultivated throughout Japan. According to our earlier investigation (unpublished data) of myoga cultivators in Japan, 8 of 35 cultivators experienced contact dermatitis in the harvest season. The purpose of this study was to assess the allergenicity of myoga and its major volatile components. The volatile components of myoga were analyzed by gas chromatograph (GC). They included a-pinene, β -pinene and R-(+)-limonene. We performed a toxicity study of each of the major fragrant components of myoga using acute dermal irritation assays and the Guinea-Pig Maximization test (GPMT) in order to probe the mechanism of allergic contact dermatitis. In acute dermal irritation assays, α-pinene, β -pinene and limonene showed positive responses at concentrations of 4%; limonene oxide at 20% and myoga showed a positive response at concentrations of 100%. From the results of the GPMT, according to Kligman scores, limonene oxide was identified as an extreme skin sensitizer and myoga as a mild skin sensitizer. The results of the present study show that R-(+)-limonene is the most important allergen amongst the chemical components of myoga , and we consider it to be the reason why myoga cultivators experience allergic contact dermatitis.
关键词：Myoga (Zingiber Myoga Roscoe);Gas chromatograph (GC);Acute dermal irritation assays;The Guinea-Pig Maximization test (GPMT);Allergic contact dermatitis