文章基本信息

标题：Water-Soluble Vitamin Deficiencies in Complicated Peptic Ulcer Patients Soon after Ulcer Onset in Japan
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作者：Kazumasa MIYAKE ; Teppei AKIMOTO ; Makoto KUSAKABE 等
期刊名称：Journal of Nutritional Science and Vitaminology
印刷版ISSN：0301-4800
电子版ISSN：1881-7742
出版年度：2013
卷号：59
期号：6
页码：503-508
DOI：10.3177/jnsv.59.503
出版社：Center for Academic Publications Japan
摘要：We investigated over time whether contemporary Japanese patients with complicated peptic ulcers have any water-soluble vitamin deficiencies soon after the onset of the complicated peptic ulcers. In this prospective cohort study, fasting serum levels of water-soluble vitamins (vitamins B₁, B₂, B₆, B₁₂, C, and folic acid) and homocysteine were measured at 3 time points (at admission, hospital discharge, and 3 mo after hospital discharge). Among the 20 patients who were enrolled in the study, 10 consecutive patients who completed measurements at all 3 time points were analyzed. The proportion of patients in whom any of the serum water-soluble vitamins that we examined were deficient was as high as 80% at admission, and remained at 70% at discharge. The proportion of patients with vitamin B₆ deficiency was significantly higher at admission and discharge (50% and 60%, respectively, p <0.05) than at 3 mo after discharge (10%). In conclusion, most patients with complicated peptic ulcers may have a deficiency of one or more water-soluble vitamins in the early phase of the disease after the onset of ulcer complications, even in a contemporary Japanese population.
关键词：peptic ulcer;gastrointestinal bleeding;water-soluble vitamins