文章基本信息

标题：Influences of Maternal B12 and Methionine Intake during Gestation and Lactation on Testicular Development of Offspring in Rats
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作者：Kazuhiro YAMADA ; Nozomi MAEDA ; Junko NOGUCHI 等
期刊名称：Journal of Nutritional Science and Vitaminology
印刷版ISSN：0301-4800
电子版ISSN：1881-7742
出版年度：2013
卷号：59
期号：3
页码：238-242
DOI：10.3177/jnsv.59.238
出版社：Center for Academic Publications Japan
摘要：The influence of maternal vitamin B₁₂ malnutrition on testicular development of offspring was examined using soy protein-based B₁₂-deficient diets with or without 0.5% DL -methionine supplementation. Dams were fed the B₁₂-deficient diet throughout gestation and lactation, whereas dams in a control group were fed a control diet which contained cyanocobalamin in the B₁₂-deficient diet without methionine. Offspring born to dams fed the B₁₂-deficient diet without methionine showed poor testicular development, e.g. decreased numbers of seminiferous tubules containing healthy spermatocytes and a high ratio of apoptotic cells per all germ cells. The abnormality was rarely observed in the group fed the B₁₂-deficient diet with methionine. It was likely that the testicular abnormality of offspring was caused by B₁₂-deficiency post partum and was prevented by the methionine supplementation. These observations suggested that maternal B₁₂ nutritional status during the pre-weaning period is quite important for spermatogenesis of male offspring and that the requirement of B₁₂ for testicular development is to produce active B₁₂-dependent methionine synthase.
关键词：vitamin B12;methionine synthase;folate and methionine metabolism;testicular development;maternal nutrition