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标题：Insights on Vitamin D's Role in Cardiovascular Disease: Investigating the Association of 25-Hydroxyvitamin D with the Dimethylated Arginines
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作者：Mohamed A. ABU EL MAATY ; Sally I. HASSANEIN ; Rasha S. HANAFI 等
期刊名称：Journal of Nutritional Science and Vitaminology
印刷版ISSN：0301-4800
电子版ISSN：1881-7742
出版年度：2013
卷号：59
期号：3
页码：172-177
DOI：10.3177/jnsv.59.172
出版社：Center for Academic Publications Japan
摘要：Accumulating evidence has stipulated a strong correlation between vitamin D (vitD) deficiency and cardiovascular disease (CVD); however, a mechanistic link is missing. This study investigated the association of vitD with endothelial dysfunction parameters. Subjects comprised male patients with verified coronary artery disease (CAD) ( n =69) and age- and sex-matched controls ( n =20). 25-Hydroxyvitamin D [25(OH)D] was determined using high performance liquid chromatography with ultraviolet detection whereas asymmetric and symmetric dimethylarginine (ADMA and SDMA, respectively) were determined by liquid chromatography-mass spectrometry. Nitric oxide (NO) was determined spectrophotometrically and high-sensitivity C-reactive protein (hs-CRP) was determined using enzyme-linked immunosorbent assay (ELISA). Comparison of mean 25(OH)D concentrations of patients and controls yielded a significant result ( p =0.0002). 25(OH)D₂ was dominant in patients whereas 25(OH)D₃ was dominant in controls ( p =0.003 and 0.001, respectively). Comparison of mean ADMA and SDMA concentrations of patients exhibiting normal and suboptimal vitD yielded insignificant results ( p =0.692 and 0.998, respectively). Significant results were obtained from the comparison of mean hs-CRP and NO concentrations of patients exhibiting normal and suboptimal vitD ( p =0.035 and 0.031, respectively). Results suggest involvement of vitD with the NO system, however not via modulation of the dimethylated arginines. A potential anti-inflammatory activity for vitD is also raised.
关键词：vitamin D;cardiovascular disease;endothelial dysfunction;dimethylated arginine