文章基本信息

标题：A Case Study on the Association of Variation of Bitter-Taste Receptor Gene TAS2R38 with the Height, Weight and Energy Intake in Japanese Female College Students
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作者：Hiroko INOUE ; Kimiko YAMAKAWA-KOBAYASHI ; Yuichi SUZUKI 等
期刊名称：Journal of Nutritional Science and Vitaminology
印刷版ISSN：0301-4800
电子版ISSN：1881-7742
出版年度：2013
卷号：59
期号：1
页码：16-21
DOI：10.3177/jnsv.59.16
出版社：Center for Academic Publications Japan
摘要：One of the critical factors that determines individual differences in dietary behavior and nutritional status is the sensory-affecting quality of food, in particular its taste. Variation of one bitter taste receptor gene, TAS2R38 , which is associated with the differential sensitivity to phenylthiocarbamide (PTC) and 6- n -propylthiouracil (PROP), has been demonstrated to affect the dietary intake pattern. A case study was performed to examine the association of the TAS2R38 genotypes/haplotypes with the body size (height, weight and BMI) and with the food and nutrient intake. Eighty-four college students, all females, with an age range of 18-21 y were recruited from the University of Shizuoka. The genotypes of two common single nucleotide polymorphisms in TAS2R38 (A49P and I296V) were determined by PCR-restriction fragment length polymorphism (RFLP) method. The height, weight and body mass index (BMI), and (in a subgroup of 47 subjects) food and nutrition intake estimated from 3 d of food recording, were compared between homozygotes for the PTC/PROP-nontaster haplotype (AI haplotype) and carriers with the PTC/PROP-taster haplotype (PV haplotype). The results show that the homozygotes with AI haplotype were taller and heavier than the carriers of PV haplotype, while BMI values were similar between them. The former group also had higher energy and carbohydrate intakes than the latter group. Neither vegetable nor dairy product intake was different between the homozygotes with AI haplotype and the carriers of PV haplotype. In conclusion, the PTC/PROP-nontaster TAS2R38 genotype/haplotype was associated with height and weight but not with BMI, which may in turn have influenced the energy and carbohydrate intakes.
关键词：food intake;BMI;PROP;dietary behavior