文章基本信息

标题：Anti-Allergic Properties of a Matured Fruit Extract of the Date Palm Tree (Phoenix dactylifera L.) in Mite-Sensitized Mice
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作者：Koji KARASAWA ; Hajime OTANI
期刊名称：Journal of Nutritional Science and Vitaminology
印刷版ISSN：0301-4800
电子版ISSN：1881-7742
出版年度：2012
卷号：58
期号：4
页码：272-277
DOI：10.3177/jnsv.58.272
出版社：Center for Academic Publications Japan
摘要：The effects of oral ingestion of a hot water extract of matured fruit of the date palm tree ( Phoenix dactylifera L.) on allergic responses were investigated in mite-sensitized mice. Sneezing and nose rubbing events in mice given a date extract-added diet were significantly lower than in those given an extract-free (control) diet. The serum total and mite antigen-specific immunoglobulin (Ig) E levels, and the number of spleen interleukin-4⁺CD4⁺, IgE⁺B220⁺ and FcεRIα⁺CD117⁺ cells was significantly lower in mice given the date extract-added diet than in those given the control diet. Chlorogenic acid, pelargonin and ferulic acid significantly reduced the number of IgE⁺B220⁺ cells, while chlorogenic acid and pelargonin significantly decreased the number of FcεRIα⁺CD117⁺ cells in mouse spleen cell cultures. These results suggest that some polyphenols in the date may reduce mite-induced allergic symptoms in mice via a decrease in the number of IgE-producing plasma cells and high-affinity IgE receptor-expressing mast cells.
关键词：anti-allergic property;date polyphenol;Th1/Th2 balance;IgE-producing plasma cell;mast cell